Elucidating Hepatic Lipidosis in Stray Cats Through Serum Biochemistry, Liver Histopathology and Liver RNA Expression of PPAR-δ and PPAR-γ

Early detection of feline hepatic lipidosis (FHL) with appropriate treatment can increase prognosis significantly. This study looks into the serum biochemistry and lipid composition liver samples in a group stray cats (N=18) collected from pounds Klang Valley, Malaysia. Alanine aminotransferase (ALT) blood was used to detect for damage possibly due FHL, confirmed through light microscopy, (triglyceride, cholesterol, creatinine, urea), triglyceride cholesterol concentrations, RNA expression droplet regulators peroxisome proliferator-activated receptors (PPARs). Differing severity FHL were divided grouped using an adapted scoring method observing fatty change (FCL) trends between FCL groups investigated. Elevated ALT reflective increasing observed elevated concentrations TAG levels. Serum decreased heightened pointing acid oxidation restoration liver, supported by PPAR-γ which also propose macrophage activation recovery alongside PPAR-δ lipogenesis inflammatory reactions. creatinine urea levels overall intact function cat samples.